Vitamin E better than Placebo and Pioglitazone for Nonalcoholic Steatohepatitis

Image via Wikipedia

In this NEJM study, 800 IU of vitmain E was given for 96 weeks. This was compared to placebo and Pioglitazone. The target was histological improvement. Vitamin E was associated with improvements compared to placebo. Liver enzymes (a secondary marker in this study) also showed improvement.

Vitamin E was RRR--tocopherol (d--tocopherol).

NEJM -- Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis